A Ph.D. position is available in the Research group of Prof. Dirk Bumann at the Biozentrum, Basel.
Infectious diseases are a major worldwide health concern. Current therapies have become increasingly inefficient because of emerging antimicrobial resistance, while the pipeline of new drugs is drying up. To avoid a public health emergency, the entire antibiotic research
community must work together to reinvigorate research into new antibiotics. The available position will be part of the Innovative Medicines Initiative (http://www.imi.europa.eu/) project ND4BB-Translocation (http://www.imi.europa.eu/content/translocation) that will focus its efforts on identifying new ways of getting antibiotics into Gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae and preventing them from expelling the drugs before they can take effect.
In collaboration with partners from industry and European academic labs, our group will determine properties of the bacterial cell wall envelope under in vivo conditions using FACS, proteomics, and computational modeling. Our ultimate goal is a quantitative understanding of drug penetration and efflux mechanisms through the bacterial cell envelope. This will help to overcome a major barrier in development of urgently needed novel antibiotics.
The expertise in our group comprises multi-color high-speed FACS sorting, confocal microscopy, proteomics, metabolomics, microbial genetics, and in silico modeling (Nature 440, 303-7; Science 333,228-33). Group members include microbiologists, biochemists, chemists, pharmacologists, and software engineers. We are part of the Biozentrum that hosts numerous excellent labs with a wide and diverse range of interests and direct access to state-of-the art equipment (including FACSAria, FACS Fortessa, Leica SP5 and other confocal microscopes, automated microscopes, Orbitrap velos and elite mass spec, etc).
Basel offers an exciting international community with major pharmaceutical companies, an outstanding cultural life enhanced by the close proximity of France and Germany, and abundant out-door opportunities including the Alps at a ca. 60 min train ride.
Qualification:
You hold a Masters in one of the following disciplines: microbiology, biochemistry, or chemistry. You have an interest infection biology and systems biology.
How to Apply:
Please send a pdf-file containing your C.V., letter of application including your research interests and contact info of two references to Rachel Benzies (rachel.benzies@unibas.ch).
Infectious diseases are a major worldwide health concern. Current therapies have become increasingly inefficient because of emerging antimicrobial resistance, while the pipeline of new drugs is drying up. To avoid a public health emergency, the entire antibiotic research
community must work together to reinvigorate research into new antibiotics. The available position will be part of the Innovative Medicines Initiative (http://www.imi.europa.eu/) project ND4BB-Translocation (http://www.imi.europa.eu/content/translocation) that will focus its efforts on identifying new ways of getting antibiotics into Gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae and preventing them from expelling the drugs before they can take effect.
In collaboration with partners from industry and European academic labs, our group will determine properties of the bacterial cell wall envelope under in vivo conditions using FACS, proteomics, and computational modeling. Our ultimate goal is a quantitative understanding of drug penetration and efflux mechanisms through the bacterial cell envelope. This will help to overcome a major barrier in development of urgently needed novel antibiotics.
The expertise in our group comprises multi-color high-speed FACS sorting, confocal microscopy, proteomics, metabolomics, microbial genetics, and in silico modeling (Nature 440, 303-7; Science 333,228-33). Group members include microbiologists, biochemists, chemists, pharmacologists, and software engineers. We are part of the Biozentrum that hosts numerous excellent labs with a wide and diverse range of interests and direct access to state-of-the art equipment (including FACSAria, FACS Fortessa, Leica SP5 and other confocal microscopes, automated microscopes, Orbitrap velos and elite mass spec, etc).
Basel offers an exciting international community with major pharmaceutical companies, an outstanding cultural life enhanced by the close proximity of France and Germany, and abundant out-door opportunities including the Alps at a ca. 60 min train ride.
Qualification:
You hold a Masters in one of the following disciplines: microbiology, biochemistry, or chemistry. You have an interest infection biology and systems biology.
How to Apply:
Please send a pdf-file containing your C.V., letter of application including your research interests and contact info of two references to Rachel Benzies (rachel.benzies@unibas.ch).
Application Deadline : 28 February 2013
